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Plinio Cirillo¹, Mariarosaria Morello², Gisella Titolo²

¹Department of Advanced Biomedical Sciences, Division of Cardiology, University of Naples "Federico II", Via Pansini, 5, Naples, 80131, Italy. pcirillo@unina.it.

Journal of thrombosis and thrombolysis

|August 29, 2024

概括

电子烟 (ECIG) 增加了内皮细胞中的组织因子 (TF) 表达,促进了前血栓状态. 这表明ECIG可能是心血管事件的危险因素.

科学领域:

心血管研究研究心血管研究
血栓形成生物学血栓形成生物学
内皮细胞生物学内皮细胞生物学

背景情况:

电子烟 (ECIG) 被销售为更安全的烟草替代品,但心血管风险令人担忧.
以前的研究将ECIG使用与心血管影响和血小板依赖性血栓形成联系起来.
对于ECIG对组织因子 (TF) 依赖性血栓的影响仍然基本未知.

研究的目的:

调查ECIG暴露是否促进内皮细胞中的TF表达.
为了确定ECIG是否会将内皮细胞转移到前血栓性表型.
探索ECIG诱导的TF表达的潜在机制.

主要方法:

人类静脉内皮细胞 (HUVEC) 暴露于不同度的ECIG.
使用实时PCR和Western Blot来量化TF基因和蛋白质的表达.
评估了TF表面表达,活性和NF-κB通路激活.

主要成果:

在基因和蛋白质水平上,以剂量和时间依赖的方式,ECIG显著提高了TF的调节.
观察到TF表面表达和前凝剂活性增加.
NF-κB通路参与调解这些ECIG效应.

结论:

通过功能性TF表达,ECIG暴露会在内皮细胞中诱导一种前性表现型.
这些发现突出了将ECIG使用与心血管疾病联系在一起的潜在机制.
ECIG可能是血栓性心血管事件的危险因素.

关键词:

心血管疾病是什么心血管疾病在 ECIG 中,ECIG 是 ECIG 的代表.尼古丁是一种尼古丁.血栓形成的原因之一是血栓形成.组织因子组织因子

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