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在不同的瘤群体中,BCAM (基底细胞粘附分子) 蛋白质表达

Sneha Burela¹, Mengni He¹, Ioannis P Trontzas¹

¹Department of Pathology, Yale School of Medicine, New Haven, CT, 06519, USA.

Discover oncology

|August 29, 2024

概括

基底细胞粘附分子 (BCAM) 显示出作为癌症生物标志物的前景. 高BCAM表达与肺癌的更好的生存率相关,并且可以独立于PD-L1.1,预测免疫治疗反应.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
生物标志物发现发现

背景情况:

基底细胞粘附分子 (BCAM) 参与了癌症的发病.
免疫检查点的低BCAM表达和高甲基化表明对免疫检查点抑制剂 (ICI) 的潜在反应.

研究的目的:

为了评估各种癌症类型的BCAM表达模式.
确定BCAM作为免疫治疗反应预测生物标志物的潜力.
为了研究BCAM和PD-L1表达之间的相关性.

主要方法:

使用定量免疫光 (QIF) 来评估BCAM表达.
分析包括发现和验证队列中的3114名患者,涵盖7种癌症类型.
进行了BCAM和PD-L1表达之间的相关性分析.

主要成果:

在卵巢 (79.2%) 和肺 (78.5%) 瘤中,BCAM的表达很高.
在乳腺,头和膀-心血管瘤中也观察到显著的BCAM表达.
高BCAM表达与非小细胞肺癌 (NSCLC) 的改善整体存活率 (OS) 相关联.
BCAM表达与PD-L1蛋白水平没有相关性,表明了独立的预测潜力.

结论:

BCAM在多种瘤类型中表达,这表明它具有广泛的相关性.
由于BCAM与PD-L1缺乏相关性,这凸显了它作为免疫治疗的新型独立预测生物标志物的潜力.
作为癌症免疫治疗反应的预测生物标志物,BCAM需要进一步研究.

关键词:

癌症生物标志物癌症生物标志物在 PD-L1 表达式上.定量免疫光 (QIF) 是一种基底细胞粘附分子 (BCAM) 是一种基底细胞粘附分子.治疗目标治疗目标

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