相关实验视频

Updated: Jun 14, 2025

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

开发和优化一种自我微乳化药物输送系统 (SMEDDS),用于同时使用索拉费尼布和黄素

Xingzhen Huang^1,2, Lizhen Feng³, Xuefang Lu⁴

¹School of Pharmacy, Guangxi Medical University, Nanning, Guangxi, 530000, PR China. huangxingzhen@gxmu.edu.cn.

Drug delivery and translational research

|August 29, 2024

概括

一种新型的自我微乳化药物输送系统 (SMEDDS) 能够同时输送黄素和索拉芬尼,显著提高抗瘤功效. 这种配方可改善肝细胞癌治疗的药物溶解性和口服生物可用性.

科学领域:

制药科学制药科学
药物输送系统药物输送系统
纳米技术纳米技术

背景情况:

肝细胞癌 (HCC) 治疗面临着药物溶解性和生物可用性方面的挑战.
黄素和索拉费尼布是潜在的抗癌药物,其发射能力有限.
需要新的药物输送系统来提高这些化合物的疗效.

研究的目的:

开发和描述一种自我微乳化药物输送系统 (SMEDDS),用于同时使用黄素和索拉芬尼布.
评估结合SMEDDS的体外抗瘤疗效和药物释放概况.
评估同时服用药物的体外药理动力学改善,特别是口服生物可用性.

主要方法:

索拉费尼布-库尔库明自微乳化药物输送系统 (SOR-CUR-SMEDDS) 的配方,采用响应表面方法来优化.
试验室表征包括颗粒大小,多分散率指数 (PDI) 和泽塔潜力 (ZP).
在体外对HepG2细胞的抗瘤活性评估,药物释放研究和药物动力学分析.

主要成果:

SOR-CUR-SMEDDS表现出最优的纳米乳液特性 (13.48 nm大小,0.228 PDI,-12.4 mV ZP). 在这种情况下,SOR-CUR-SMEDDS具有最佳的纳米乳液特性.
该组合显示显著降低了对HepG2细胞的IC50值 (曲素为3倍,索拉芬尼为5倍).
实验室研究显示,黄素释放量增强 (79.20%),口服索拉费尼布 (1239.88倍) 和黄素 (3.64倍) 的生物可用性大幅增加.

结论:

开发的SOR-CUR-SMEDDS有效地提高了黄素和sorafenib的可溶性和抗瘤功效.
这种新的配方显著提高了这两种药物的口服生物可用性.
SMEDDS代表了一种有前途的策略,用于提高结合性肝细胞癌治疗的治疗潜力.

关键词:

联合管理联合管理库尔库明是一种黄素.药物动力学研究药物动力学研究质量评估质量评价质量评价这里是SMEDDS.索拉费尼布 (Sorafenib) 是一种

更多相关视频

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

相关概念视频

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...

Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...