来自Cissus quadrangularis植物的内菌是生物活性化合物的有希望的来源
Vanita S Awari1, Vitthal T Barvkar1, Avinash B Ade1
1Department of Botany, Savitribai Phule Pune University, Pune, 411007, India.
概括
从Cissus quadrangularis中分离出的内菌产生植物,为骨折愈合提供了潜在的替代来源. 这些真菌还表现出显著的抗氧化剂和激素清除活动.
科学领域:
- 药理学是指药理学,即药理学是指药理学.
- 菌类学 菌类学是指菌类学.
- 药用植物学 医学植物学
背景情况:
- 四角 (Cissus quadrangularis) 是一种传统的药用植物,以其骨愈合特性而闻名,并归因于植物醇.
- 植物资源有限,需要探索这些生物活性化合物的替代来源.
- 居住在药用植物中的内性真菌是新型代谢物的潜在储库.
研究的目的:
- 从Cissus quadrangularis中分离和描述内性真菌.
- 为了调查植物及其内性真菌分离物中的植物的存在.
- 评估植物和真菌提取物的抗氧化和激素清除潜力.
主要方法:
- 从Cissus quadrangularis茎中分离和识别了内菌.
- 植物和真菌提取物中植物醇的定性分析.
- 使用激素清除试验 (IC50测定) 提取甲醇和评估抗氧化活性.
主要成果:
- 他们分离了三种内菌:Collettotrichum gloeosporioides,Collettotrichum siamense和Phoma sp. 这三种内菌.
- 在C. quadrangularis茎提取物和所有三个孤立的内菌提取物中检测到植物醇.
- 来自植物和内植物的甲醇提取物表现出显著的抗氧化和激素清除活性,具有显著的IC50值.
结论:
- 四角 (Cissus quadrangularis) 的内菌是一种可行的植物的来源.
- 已识别的内植物具有抗氧化特性,可能有助于植物的药用价值.
- 需要进一步研究从这些内源性分离物中获得的植物的骨愈合能力.
相关概念视频
Introduction to Plant Diversity
50.7K
From Water to Land
50.7K
Gene Regulation in Microbial Communities: Quorum Sensing
913
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
913
Fungal Group Zygomycota
2.1K
Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
2.1K
Fungal Phylum Basidiomycota
2.1K
Basidiomycota is a diverse phylum of fungi that includes ecologically significant decomposers such as white rot fungi, symbionts like mycorrhizal fungi, plant pathogens such as rusts and smuts, and edible species like Agaricus bisporus (the common button mushroom). These fungi play crucial roles in nutrient cycling, symbiotic relationships, and even human health. Their defining feature is the basidium, a microscopic club-shaped structure responsible for producing basidiospores.Fruiting Bodies...
2.1K
Microbe-Plant Interactions
85
Microbe-plant interactions represent a dynamic spectrum of associations shaped by intricate chemical signaling. These interactions can be neutral, beneficial, or detrimental, and profoundly influence plant physiology, growth, and ecosystem function. The plant microbiome, comprising bacteria, fungi, archaea, protists, and viruses, plays a pivotal role in mediating these effects through surface colonization, internal colonization, or systemic symbiosis.Mutualistic associations, particularly with...
85
Antifungal Agents
89
Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
89


