传染性疾病 传染性疾病
Herman Li1,2, Niccolò Terrando3,4,5, Harris A Gelbard6,7,8,9
1Center for Neurotherapeutics Discovery, Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA.
Advances in neurobiology
|August 29, 2024
概括
由于COVID-19等感染引起的外周炎症可能会损害大脑,影响微质细胞. 向MLK3和LRRK2通路可能会治疗COVID-19 (PASC) 和艾滋病毒相关的神经认知障碍 (HAND) 后急性后果的神经问题.
科学领域:
- 神经免疫学 神经免疫学
- 传染病神经学 传染病神经学
- 神经炎症是一种神经炎症.
背景情况:
- 微质细胞,大脑的免疫细胞,与神经退行有关,并且可以在感染后维持炎症.
- 周围炎症,如COVID-19中所见,影响神经免疫环境,导致微质病.
- 来自HIV-1相关的神经认知障碍 (HAND) 的经验教训有助于对慢性神经炎症的理解.
研究的目的:
- 讨论SARS-CoV-2感染如何导致神经炎症和COVID-19 (PASC) 后急性后果.
- 探索微质在PASC和HAND病原发生中的作用.
- 为了确定PASC和HAND的治疗目标.
主要方法:
- 关于神经退行性和传染性疾病中微质功能现有文献的综述.
- 分析SARS-CoV-2对神经血管和神经免疫路径的影响.
- 检查混合血统激酶3 (MLK3) 和富含白的重复激酶 (LRRK2) 在炎症途径中的作用.
主要成果:
- 肺部SARS-CoV-2感染可以诱导神经血管和神经免疫性炎症,导致PASC.
- 微质功能障碍,由外周炎症加剧,在PASC和HAND中起着至关重要的作用.
- MLK3和LRRK2被确定为关键调节器的炎症和亡途径相关的PASC和手的病原体.
结论:
- 针对MLK3和LRRK2途径为PASC和HAND提供了一种协同治疗策略.
- 了解微质对病毒感染的反应对于治疗相关的神经系统并发症至关重要.
- 对艾滋病毒的综合抗逆转录病毒疗法 (cART) 强调了对神经认知健康的边缘感染管理的长期影响.
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