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Infection01:20

Infection

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Sexually Transmitted Infections01:26

Sexually Transmitted Infections

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Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
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Intracellular Movement of Viruses and Bacteria01:10

Intracellular Movement of Viruses and Bacteria

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Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Author Spotlight: Advancing Rapid Detection of Respiratory Pathogens Using Microfluidic Chip
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传染性疾病 传染性疾病

Herman Li1,2, Niccolò Terrando3,4,5, Harris A Gelbard6,7,8,9

  • 1Center for Neurotherapeutics Discovery, Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA.

Advances in neurobiology
|August 29, 2024
PubMed
概括
此摘要是机器生成的。

由于COVID-19等感染引起的外周炎症可能会损害大脑,影响微质细胞. 向MLK3和LRRK2通路可能会治疗COVID-19 (PASC) 和艾滋病毒相关的神经认知障碍 (HAND) 后急性后果的神经问题.

关键词:
新冠病毒疾病2019年人类免疫缺陷病毒人类免疫缺陷病毒人类免疫缺陷病毒相关的神经认知障碍炎症 炎症是一种炎症.富含白素的重复激酶2微质细胞中的微质细胞混合血统激酶 3 的混合血统激酶2019年新冠肺炎疾病的后急性后果严重急性呼吸系统综合征冠状病毒2

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Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
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科学领域:

  • 神经免疫学 神经免疫学
  • 传染病神经学 传染病神经学
  • 神经炎症是一种神经炎症.

背景情况:

  • 微质细胞,大脑的免疫细胞,与神经退行有关,并且可以在感染后维持炎症.
  • 周围炎症,如COVID-19中所见,影响神经免疫环境,导致微质病.
  • 来自HIV-1相关的神经认知障碍 (HAND) 的经验教训有助于对慢性神经炎症的理解.

研究的目的:

  • 讨论SARS-CoV-2感染如何导致神经炎症和COVID-19 (PASC) 后急性后果.
  • 探索微质在PASC和HAND病原发生中的作用.
  • 为了确定PASC和HAND的治疗目标.

主要方法:

  • 关于神经退行性和传染性疾病中微质功能现有文献的综述.
  • 分析SARS-CoV-2对神经血管和神经免疫路径的影响.
  • 检查混合血统激酶3 (MLK3) 和富含白的重复激酶 (LRRK2) 在炎症途径中的作用.

主要成果:

  • 肺部SARS-CoV-2感染可以诱导神经血管和神经免疫性炎症,导致PASC.
  • 微质功能障碍,由外周炎症加剧,在PASC和HAND中起着至关重要的作用.
  • MLK3和LRRK2被确定为关键调节器的炎症和亡途径相关的PASC和手的病原体.

结论:

  • 针对MLK3和LRRK2途径为PASC和HAND提供了一种协同治疗策略.
  • 了解微质对病毒感染的反应对于治疗相关的神经系统并发症至关重要.
  • 对艾滋病毒的综合抗逆转录病毒疗法 (cART) 强调了对神经认知健康的边缘感染管理的长期影响.