固体器官移植接受者的不良妊娠结果:系统性审查和元分析
Jennifer H Yo1,2,3, Neville Fields4,3, Wentao Li5,6
1Department of Nephrology, Monash Health, Melbourne, Victoria, Australia.
JAMA network open
|August 29, 2024
概括
固体器官移植接受者的怀孕有明显更高的孕前症,早产和低出生体重的风险. 然而,在怀孕期间排斥或失去全移植的风险仍然很低.
科学领域:
- 生殖医学 生殖医学
- 移植手术 移植手术
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 固体器官移植接受者面临着不良妊娠结果的高风险.
- 关于这些风险和怀孕期间全移植结果的当代数据有限.
研究的目的:
- 评估固体器官移植与不良妊娠结果之间的关联.
- 量化孕妇移植受体体中全移植排斥和损失的发生率.
主要方法:
- 对队列和病例控制研究 (2000-2024) 的系统审查和元分析.
- 在PubMed/MEDLINE,EMBASE和Scopus数据库中进行了搜索.
- 包括22项涉及9300多万怀孕的研究.
主要成果:
- 器官移植接受者有显著增加的风险:孕前 (aOR 5.83),早产 (aOR 6.65) 和低出生体重 (aOR 6.51).
- 急性异位移植排斥的发生率为2.39%.
- 怀孕期间全移植损失的发生率为1.55%.
结论:
- 固体器官移植接受者的怀孕与重大不良结果的风险增加4-6倍有关.
- 在怀孕期间移植体排斥或丢失的整体风险很低.
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