药房纳洛常规和社区阿片类药物死亡率随着时间的推移
Ziming Xuan1,2, Alexander Y Walley3, Shapei Yan3
1Department of Community Health Sciences, Boston University School of Public Health, Boston, Massachusetts.
药房通过常规订单发放纳洛与阿片类药物过量死亡的显著减少有关. 这支持扩大纳洛的获取,包括非处方药的选择,为全面的过量预防战略.
科学领域:
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
- 卫生政策 卫生政策
背景情况:
- 过量服用阿片类药物的死亡仍然是一个关键的公共卫生危机.
- 基于药房的纳洛分发已经扩大,但它对死亡率的影响需要评估.
- 很少有研究分析了药房常规订购纳洛计划在减少社区一级死亡事故中的有效性.
研究的目的:
- 评估药房常规订单纳洛分发与阿片类药物死亡率之间的关联.
- 为了比较社区的阿片类药物死亡率与没有常规纳洛计划的社区.
- 为有关纳洛获取和阿片类药物过量预防的政策提供信息.
主要方法:
- 从2013年至2018年,对351个马萨诸塞州市镇进行了回顾性,中断的时间序列分析.
- 使用了从零售药店处分纳洛常规订单的数据 (70%的覆盖率).
- 分析了每10万人口的市政阿片类药物死亡率,并根据社会人口统计和预防因素进行调整.
主要成果:
- 实施常规纳洛的市政当局的阿片类药物死亡率较高.
- 在实施后,观察到阿片类药物死亡率显著下降 (年化率比,0.84;P <.001).
- 检测到死亡率没有显著的即时变化,表明逐渐的影响.
结论:
- 社区药房通过常设订单发放纳洛与阿片类药物过量死亡的逐渐减少有关.
- 调查结果支持扩大纳洛的获取,包括非处方可用性.
- 基于药房的纳洛计划是多方面的阿片类药物过量预防策略的宝贵组成部分.
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