在之前住院的COVID-19患者中长期的大脑雾和认知障碍
Barbara Junco1, Daniel Samano Martin Del Campo1,2, Vela Karakeshishyan1
1Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, United States of America.
PloS one
|August 29, 2024
概括
COVID-19的严重程度与持续的脑雾和感染后两年的认知缺陷有关,特别是在多样化的人口中. 进一步的研究对于改善长期COVID神经效应的检测和治疗至关重要.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 关于COVID-19的长期认知和精神影响的研究有限,特别是在不同患者群体中.
- 经过急性COVID-19后报告了脑雾和认知缺陷,但与临床严重性的长期关联尚未得到充分确立.
研究的目的:
- 在一个多样化的队列中,描述急性后COVID-19的神经心理后续.
- 调查COVID-19临床严重程度与持续的大脑雾和大约两年感染后的认知缺陷之间的关联.
主要方法:
- 一项涉及41名因COVID-19住院的成年患者的横截面研究.
- 通过远程电池进行神经心理评估,在出院两年后进行,COVID-19的严重程度按国家早期预警分数2进行索引.
- 统计分析包括皮尔森的r相关性,独立样本t测试,多重回归和ANCOVA来评估关联和群体差异.
主要成果:
- 感染后两年,COVID-19的严重程度与脑雾症状增加 (r = .34) 和全球认知功能恶化 (r = - .36) 相关.
- 难以集中注意力 (r = .46),感觉脱离 (r = .41),和嗜睡 (r = .40) 是与COVID-19严重程度相关的关键脑雾症状.
- 患者的认知表现通常低于平均水平 (全球认知z分数:M = -96),性别和种族影响了个体测试表现.
结论:
- COVID-19的临床严重程度与持续的神经心理缺陷有关,包括感染后两年的大脑雾和认知障碍.
- 研究结果强调,需要继续研究COVID-19的长期影响,特别是在代表性不足和健康差异较大的人群中.
- 改进的理解可以提高对COVID-19后认知能力下降风险的个体的检测和治疗.
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