在多民族人群中使用MRI检查乳腺癌分子亚型
Nazimah Ab Mumin1,2, Marlina Tanty Ramli Hamid2, Jeannie Hsiu Ding Wong1
1Faculty of Medicine, Department of Biomedical Imaging, University of Malaya Research Imaging Centre, Universiti Malaya, Kuala Lumpur, Malaysia.
PloS one
|August 29, 2024
概括
磁共振成像 (MRI) 功能可以帮助区分乳腺癌亚型,包括三阴性乳腺癌 (TNBC),并评估瘤的攻击性. 这些发现适用于不同种族的人口,有助于诊断和治疗规划.
科学领域:
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
- 医疗成像医学成像
背景情况:
- 准确的乳腺癌亚型鉴定对于有效的诊断,管理和预后至关重要.
- 分子亚型和瘤的攻击性影响治疗策略和患者的治疗结果.
研究的目的:
- 调查磁共振成像 (MRI) 特征与乳腺癌分子亚型在多民族队列中的关联.
- 为了确定MRI特征是否可以预测瘤的攻击性和受体状态.
主要方法:
- 对未经治疗的侵袭性乳腺癌患者的回顾性分析.
- 使用ACR-BIRADS标准,瘤大小和明显扩散系数 (ADC) 值记录MRI特征.
- 统计分析包括奇平方,克鲁斯卡尔-瓦利斯,曼·惠特尼U测试和多项逻辑回归,以将MRI特征与分子亚型,受体状态,等级,LVI和ALN相关联.
主要成果:
- 三重阴性乳腺癌 (TNBC) 与边缘增强和周围胀有关.
- 丰富HER-2的瘤与更大的尺寸有关,而光样类癌症则表现出不规则的形状和有限的边缘.
- 边缘增强与较高的瘤等级相关,以及带有阳性骨淋巴结的周围胀.
结论:
- 特定的MRI特征可以有效地区分乳腺癌分子亚型.
- 磁力共振成像特征与受体状态和瘤的攻击性有关.
- 这些发现对于改善乳腺癌评估而言,在多民族人群中具有相关性.
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