青少年和年轻成年人使用乙孕避孕植入物时体质指数的变化
Hunter J Wernick1, Mahmoud Abdel-Rasoul, Elise D Berlan
1Division of Adolescent Medicine, Nationwide Children's Hospital, the Department of Pediatrics and the Center for Biostatistics, The Ohio State University College of Medicine, and the Biostatistics Resource at Nationwide Children's Hospital (BRANCH), Columbus, Ohio.
Obstetrics and gynecology
|August 29, 2024
概括
使用乙格斯特勒植入物的青少年体质指数 (BMI) 变化与使用德波基酸 (DMPA) 的青少年体质指数 (BMI) 变化相似,并且高于对照组. 这些BMI变化可能没有临床意义.
科学领域:
- 生殖健康 生殖健康
- 青少年医学 青少年医学
- 内分泌学 在内分泌学.
背景情况:
- 青少年和年轻人的避孕选择对生殖健康至关重要.
- 了解不同避孕方法对身体质量指数 (BMI) 的影响对于患者咨询很重要.
- 以前的研究表明,激素避孕药和体重变化之间存在潜在的联系.
研究的目的:
- 为了比较体质指数 (BMI) 变化超过36个月的青少年和年轻成年人使用etonogestrel植入物与仓库medroxyprogesterone乙酸 (DMPA) 和对照组.
- 评估这些群体中BMI体重类别变化的发生率.
- 为年轻人提供关于避孕药的使用和预期的BMI轨迹的咨询数据.
主要方法:
- 使用了追溯纵向队列研究设计.
- 参与者包括经月经后的青少年和年轻成年人,在2010年至2017年期间被分配为出生时的女性,开始服用乙格斯特勒,DMPA或体重中性/没有避孕药.
- 用线性混合效应建模来比较随时间推移的BMI,并分析BMI重量类别的变化.
主要成果:
- 这项研究包括20409名符合条件的患者,860名患者接受了乙凝治疗,1817名患者接受了DMPA治疗,17732名患者接受了对照组治疗.
- 与对照组相比,乙格斯特组在36个月内显示出明显更高的平均BMI差异 (+1.0,P <.01).
- 与对照组相比,DMPA组在36个月内也显示出更高的平均BMI (+1.3,P <.01).
- 在所有组中,BMI体重类别的增加并不常见.
结论:
- 青少年和年轻成年人开始使用乙格斯特勒植入物经历的BMI变化与DMPA患者相似,比对照组更大.
- 观察到的BMI差异通常很小,可能不代表临床上有重大问题.
- 研究结果为医疗保健提供者提供了有价值的见解,为年轻患者提供关于BMI预期的etonogestrel植入物的咨询.
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