治疗阻塞性睡眠呼吸暂停的患者的表型化,具有持续的客观性警觉障碍或主观性嗜睡
Pierre Tankéré1, Jacques Taillard2, Emeric Stauffer3
1Center for Sleep Medicine, Croix-Rousse Hospital, Hospices Civils de Lyon, Lyon, France; Grenoble Alpes University, HP2 Laboratory (Hypoxia Pathophysiology), INSERM U1300 Grenoble, France; Lyon Neuroscience Research Center, PAM Team, INSERM U1028 / CNRS UMR 5292 / Lyon 1 University, Lyon, France.
Sleep medicine
|August 29, 2024
概括
剩余的嗜睡和警觉性受损影响超过三分之一的阻塞性睡眠呼吸暂停 (OSA) 患者,尽管治疗. 吸烟和高BMI是警觉性受损的关键风险因素,即使没有主观的嗜睡.
科学领域:
- 睡眠医学 睡眠医学
- 肺部病理学 肺部病理学
- 神经学 神经学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与重大风险有关,包括事故和心血管问题.
- 一个显著的百分比的OSA患者经历持续的嗜睡,尽管治疗.
- 在接受治疗的OSA患者中,导致残留的嗜睡和警觉障碍的因素尚不清楚.
研究的目的:
- 调查残留主观嗜睡的决定因素.
- 为了确定与治疗OSA患者的客观性警觉受损相关的因素.
- 为了比较有或没有残留嗜睡或警觉性受损的患者之间的临床和多睡眠学参数.
主要方法:
- 用维护清醒测试 (MWT) 和爱普沃思睡眠度量 (ESS) 评估了一组141名为OSA治疗的患者.
- 收集了临床数据,多睡眠学参数和事故史.
- 使用多变量逻辑回归来确定与MWT和ESS结果相关的变量.
主要成果:
- 超过三分之一的患者表现出客观性警觉受损和/或主观性嗜睡.
- 事故史,吸烟和ESS得分较高与客观警觉性受损有关.
- 客观警觉性受损但没有主观嗜睡的患者往往有更高的BMI,并且是吸烟者.
结论:
- 在接受治疗的OSA患者中,很大一部分患者经历了持续的嗜睡或警觉性受损.
- 综合评估,包括事故史和并发症,对于管理OSA患者至关重要.
- 高BMI的吸烟者需要特别注意,因为他们可能会在没有主观投诉的情况下降低警觉.
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