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Magnetic Resonance Imaging01:24

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
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通过定量梯度回声MRI检测到的多发性硬化症中增加了周周结膜膜损伤梯度.

Amjad Samara1, Biao Xiang1, Bradley Judge2

  • 1Department of Neurology, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA.

Multiple sclerosis and related disorders
|August 29, 2024
PubMed
概括

多发性硬化症 (MS) 从心室显示出更的乳头组织完整度梯度,与疾病持续时间和残疾有关. 这支持了表面的病理,可能是CSF介导的.

关键词:
这就是为什么MRI是MRI.多发性硬化症是多发性硬化症.定量梯度回忆回声 (qGRE) 是一种定量梯度回声.泰拉姆斯 (thalamus) 是一个神经元.

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科学领域:

  • 神经成像是一种神经成像.
  • 神经学 神经学
  • 生物医学工程 生物医学工程

背景情况:

  • 多发性硬化症 (MS) 涉及乳头组织损伤,通常表现出从心室表面的"表面入"梯度.
  • 在MS中这种胸膜梯度的临床含义仍然不完全理解.

研究的目的:

  • 在MS中使用定量梯度回忆回声 (qGRE) MRI来评估组织完整性的周周结膜体梯度.
  • 为了研究这种梯度和MS患者的临床变量之间的关系.

主要方法:

  • 从MS患者和健康对照 (HC) 获得结构和qGREMRI扫描.
  • 用 qGRE 衍生出的 R2t* 值来衡量组织完整性.
  • 通过分析从心室表面辐射出同心带中的R2t*值,计算了周心室的胸膜梯度.

主要成果:

  • 与HC相比,MS患者表现出明显更的周周结膜性乳头梯度 (平均斜率为0.55与0.36;p <0.001).
  • 多发性硬化症的乳头梯度与更长的疾病持续时间 (p = 0.027) 和更高的扩展残疾状态量表 (EDSS) 分数 (p = 0.019) 相相关.
  • 在左半球和右半球的thalamic参与是对称的.

结论:

  • 在体内使用qGREMRI检测到MS中thalamic梯度的增加.
  • 这种梯度与疾病持续时间和临床残疾有关,支持MS的"表面入"病理假设.
  • 对称的thalamic参与表明潜在的脑脊液 (CSF) 介导的病理过程.