"在训练免疫力中的甘氨酸:在恒常状态和疾病中的先天免疫记忆的教育者"
Pedro Almeida1, Ângela Fernandes1, Inês Alves1
1I3S - Institute for Research and Innovation in Health, University of Porto, 4200-135, Porto, Portugal.
Carbohydrate research
|August 29, 2024
概括
训练有素的免疫力,一种天生的免疫记忆,可以被病原体甘氨酸触发. 这种甘氨酸-GBP网络为免疫系统调节提供了潜在的治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 葡萄糖生物学 葡萄糖生物学
背景情况:
- 训练有素的免疫包括先天免疫细胞的表观遗传和代谢重编程,从而增强了反应能力.
- 这种免疫记忆为宿主防御提供了好处,但也可能导致慢性炎症和自身免疫性疾病.
研究的目的:
- 审查病原体衍生型甘氨酸在诱导训练免疫的作用.
- 突出显示免疫细胞识别甘氨酸触发器中的甘氨酸结合蛋白 (GBP) 网络.
- 探索针对性甘氨酸和GBP在训练免疫中的治疗应用.
主要方法:
- 文献综述侧重于甘氨酸,GBP和训练免疫之间的相互作用.
- 对基因糖诱导的表观遗传和代谢重编程背后的机制的分析.
- 讨论实验证据和潜在的治疗策略.
主要成果:
- 病原体表面甘氨酸作为先天免疫细胞的关键"培训者".
- 免疫细胞GBP对甘氨酸的识别启动了训练免疫表型.
- 特定的甘氨酸,如β-葡萄糖和曼诺结构,是这种现象的例子.
结论:
- 甘氨酸-GBP网络对于建立免疫中心和调节训练免疫力至关重要.
- 针对甘氨酸和GBP,在训练有素的免疫相关疾病中为治疗干预提供了有希望的途径.
相关概念视频
Cell-mediated Immune Responses
67.9K
Overview
67.9K
Immunological Memory
562
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
562
Cells of the Adaptive Immune Response
972
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
972
Glycocalyx and its Functions
3.8K
The glycocalyx is a carbohydrate-rich, fuzzy-appearing layer on the outer surface of the cell membrane. It is highly hydrophilic, because of this it attracts large amounts of water to the cell's surface. This aids the cell's interaction with the watery environment and also helps it to obtain substances dissolved in the water. It is also important for cell identification, self/non-self determination, and embryonic development and is used in cell-to-cell attachments to form tissues.
3.8K
Antigens Involved in Adaptive Immunity
476
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
476
Special Features of Adaptive Immunity
779
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
779


