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在Oikopleura dioica中的双A在环境相关度下对生长和生殖有毒性

Shuai Li¹, Yi Liang², Guangtao Zhang³

¹Jiaozhou Bay National Marine Ecosystem Research Station, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.

Journal of hazardous materials

|August 29, 2024

概括

双甲 (BPA) 危害海洋生物. 即使环境中的BPA含量很低也会影响尾细胞的繁殖和基因表达,这表明目前的安全限值可能对水生生态系统来说不够.

科学领域:

环境毒理学环境毒理学
海洋生物学海洋生物学
生态毒理学生态毒理学

背景情况:

双A (BPA) 是水生环境中广泛存在的内分泌干扰物.
尾动物是丰富的中动物浮游生物,对海洋生态系统至关重要.
关于BPA对尾细胞的影响,有有限的毒理学数据.

研究的目的:

为了评估环境相关的双A (BPA) 度对尾性Oikopleura dioica的毒性.
调查BPA暴露的形态和转录学影响.
评估当前环境BPA度对海洋动物浮游生物的安全性.

主要方法:

对Oikopleura dioica暴露于BPA度在2.5至150μg/L之间.
评估生存率 (LC50),体质生长,生殖腺发育和生殖.
转录组分析以确定分子水平对BPA的反应.

主要成果:

奥伊科普勒拉二氧化物对BPA具有很高的敏感性,LC50为142μg/L.
暴露于125μg/L的BPA显著抑制了生长,生殖和生殖腺发育.
即使是环境安全的度 (2.5μg/L) 也会影响女性的生育能力和男性的基因表达,这表明男性在分子水平上更高的敏感性.

结论:

在O. dioica雄性中,BPA暴露会破坏消化和代谢途径.
目前的BPA环境安全度可能不足以保护海洋生态系统.
尾细胞是内分泌干扰化学污染的敏感指标.

关键词:

双 A 是一种双.对环境安全的度度.海洋尾虫类动物海洋尾虫类动物毒理反应毒理反应文字转录学 (Transcriptomics) 是一个学科.

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