抗氧素耐药的葡萄球菌 spp. : 巴西新生儿重症监护室死亡人数的影响 - 面对完美的风暴
Isadora Caixeta da Silveira Ferreira1, Ralciane de Paula Menezes2, Thiago Alves de Jesus3
1Postgraduate Program in Health Sciences, Faculty of Medicine, Federal University of Uberlândia, Minas Gerais, Brazil.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|August 29, 2024
概括
新生儿中抗氧素的葡萄球菌 (ORS) 感染是一个重大问题,导致住院时间更长和死亡率更高. 新生儿重症监护病房迫切需要有效的管理和预防策略.
科学领域:
- 新生儿重症监护室 (NICU) 的感染.
- 新生儿抗菌耐药性 在新生儿中抗菌耐药性
- 葡萄球菌 spp. 葡萄球菌 spp. 流行病学流行病学
背景情况:
- 抗氧素的葡萄球菌 (ORS) 感染对脆弱的新生儿构成严重威胁.
- 了解ORS的发病率,风险因素和结果对于改善新生儿护理至关重要.
研究的目的:
- 分析与新生儿ORS感染相关的发病率,危险因素,抗菌素敏感性和死亡率.
- 确定导致ORS感染的关键因素及其对患者结果的影响.
主要方法:
- 追溯观察性描述性队列研究,分析2015年1月至2022年6月新生儿的医疗记录.
- 通过国家医疗保健安全网络,每天对参与者进行监测.
主要成果:
- 在1610名新生儿中,有193名 (12%) 患有ORS感染,主要是血液感染 (96.8%).
- 从2016年到2022年,发生率下降了51.8%. 第四代头素的使用是显著的风险因素 (OR=14.36).
- 葡萄球菌表皮菌是最常见的 (60.1%),其中2%是广泛耐药 (XDR) 病原体. ORS感染延长了住院时间,增加了死亡率 (10.2%至19.2%).
结论:
- ORS感染的高发病率与延长住院和增加死亡率有关.
- 这种情况代表了一个"完美风暴",需要紧急干预,在NICU中进行管理和预防.
- 斯塔菲洛科克斯 (Staphylococcus capitis) 被确定为最致命的物种,强调需要有针对性的战略.
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