分析与hirudotherapy相关的抗生素耐药性感染
Philip R Brauer1, Malaak Saadah2, Michael A Fritz1
1Head and Neck Institute, The Cleveland Clinic, Cleveland, OH, USA.
American journal of otolaryngology
|August 29, 2024
概括
与吸血虫治疗相关的抗生素耐药性感染越来越令人担忧,通常对多种药物产生耐药性. 这项研究突出了hirudotherapy相关感染中多药耐药性的严重性.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 全球越来越关注抗生素耐药性的问题.
- 血漏疗法 (hirudotherapy) 是一种具有潜在感染风险的替代治疗方法.
- 在hirudotherapy后的感染中评估抗生素耐药性至关重要.
研究的目的:
- 评估与水治疗相关的抗生素耐药性感染的发生率和特征.
- 分析这些感染中抗生素耐药性的模式.
- 在hirudotherapy中描述预防性抗生素的使用.
主要方法:
- 从FDAMAUDE数据库 (2012-2021) 中检索了涉及hirudotherapy的不良事件报告.
- 通过细菌培养或抗生素后感染来定义抗生素耐药性.
- 分析了细菌物种和抗生素耐药性概况的确诊病例.
主要成果:
- 鉴定了与hirudotherapy相关的19例抗生素耐药性病例,其中16例与患者受伤有关.
- 通常隔离的细菌包括Aeromonas hydrophilia (68.4%) 和Vibrio vulnificus (15.8%).
- 九例病例 (47.4%) 呈现多药性耐药性,常见于诺基诺,三甲胺-硫甲醇和埃尔塔尼姆.
结论:
- 来自hirudotherapy的抗生素耐药性感染往往表现出多种药物耐药性.
- 观察到对埃尔塔尼姆等最后手段抗生素的耐药性.
- 调查结果表明,多药耐药性的趋势比以前报告的更为严重,强调需要保持警.
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