YAP/TAZ机械信号在脊髓网和施莱姆运河细胞功能障碍中的作用
Rajanya Ghosh1, Samuel Herberg2
1Department of Ophthalmology and Visual Sciences, Center for Vision Research, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Vision research
|August 29, 2024
概括
具有PDZ结合动机 (TAZ) 的是关联蛋白 (YAP) /转录协活性剂通路在青光眼中至关重要. 它对眼细胞中的机械压力和生化因素做出反应,影响疾病的进展.
科学领域:
- 眼科医生 眼科 眼科
- 细胞生物学 细胞生物学
- 生物力学 生物力学
背景情况:
- 玻璃眼瘤的特征是眼内压力增加,通常与状网 (TM) 和施莱姆运河 (SC) 的细胞外基质 (ECM) 变化有关.
- 机械信号通路,特别是YAP/TAZ,在细胞对机械线索和ECM属性的反应中起着关键作用.
研究的目的:
- 审查YAP/TAZ机械信号在TM和SC细胞中的作用.
- 探索机械力和生化调节器在青光眼病原体中的相互作用.
- 确定具有翻译潜力的未来研究方向.
主要方法:
- 对过去十年发表的研究进行了全面的文献综述.
- 在机械应力下对眼细胞中YAP/TAZ信号传递的研究分析.
- 检查YAP/TAZ与关键生化途径 (TGF-β2,葡萄皮质,Wnt,LPA,VEGF,氧化应激) 之间的交叉关系.
主要成果:
- 在TM和SC细胞中,YAP/TAZ信号传递是细胞对ECM硬化和循环拉伸反应的关键调解者.
- 生物化学因素显著调节YAP/TAZ活性,影响与青光眼相关的细胞变化.
- 在YAP/TAZ和与眼相关的各种途径之间存在复杂的信号交叉.
结论:
- YAP/TAZ机械传导是青光眼发育和进展的关键途径.
- 针对YAP/TAZ信号传输,为眼治疗提供了一个有前途的治疗途径.
- 需要进一步的研究,以充分阐明调节YAP/TAZ在青光眼中的治疗潜力.
相关概念视频
Tension Response at Adherens Junctions
2.6K
The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
2.6K
Cell-matrix's Response to Mechanical Forces
2.6K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue.
Anchoring junctions mechanically attach a cell to the...
Anchoring junctions mechanically attach a cell to the...
2.6K
Mechanically-gated Ion Channels
6.3K
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
6.3K
Tight Junctions
5.2K
Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...
5.2K
Cell Motility through Blebbing
1.9K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
Blebbing Through the Matrix
In multicellular...
1.9K
Mechanism of Lamellipodia Formation
2.5K
Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
2.5K


