左心室血栓患者的临床表型和结果:无监督的集群分析
Aloysius S T Leow1, Fang Qin Goh1, Benjamin Y Q Tan2
1Department of Medicine, National University Health System, Singapore.
概括
确定了两个患有左心室血栓 (LVT) 的患者群. 2组患者的结果更差,包括较低的LVT分辨率和较高的死亡率,无论治疗方式如何.
科学领域:
- 心脏病学 心脏病学
- 医疗信息学 医疗信息学
- 临床研究 临床研究
背景情况:
- 左心室血栓 (LVT) 呈现出不同的临床情景和结果.
- 识别不同的患者个人资料对于量身定制的治疗和预后至关重要.
研究的目的:
- 利用集群分析来识别LVT患者的独特临床概况.
- 为了比较已识别的患者集群之间的临床特征,治疗策略和结果.
主要方法:
- 从第三级中心的心声图数据库 (2011年3月 - 2021年1月) 来对472名LVT患者的回顾性分析.
- 应用TwoStep集群分析,使用19个变量来识别患者子组.
主要成果:
- 确定了两个不同的LVT患者群.
- 集群1 (52.3%) 包含较年轻的患者,伴随性疾病较少,心肌梗塞后LVT分辨率较高.
- 2组患者患缺血性心肌病的发病率较高,LVT分辨率降低,所有原因死亡率增加,独立于治疗和LVT特征.
结论:
- 通过集群分析确定了两种不同的LVT临床表型.
- 这些表型的特点是独特的基线属性和显著不同的预后.
- 这些发现凸显了基于临床形状的LVT患者个性化管理策略的需要.
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