粮食不安全与MASLD患病率和肝脏相关死亡率的关联
Zobair M Younossi1, Shira Zelber-Sagi2, Carina Kuglemas3
1The Global NASH Council, Washington DC, USA; Beatty Liver and Obesity Research Program, Inova Health System, Falls Church, VA, USA.
Journal of hepatology
|August 29, 2024
概括
粮食不安全与全球代谢功能障碍相关的脂肪性肝病 (MASLD) 患病率有关. 较高的MASLD率与高收入国家的粮食不安全相关,但低收入国家的MASLD率较低,突出区域差异.
科学领域:
- 全球健康 全球健康
- 肝病学 肝病学是一种肝病学.
- 流行病学 流行病学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的全球健康挑战.
- 了解粮食不安全和MASLD之间的相互作用对于公共卫生干预至关重要.
研究的目的:
- 调查粮食不安全和MASLD的流行之间的全球联系.
- 在MASLD的背景下,研究粮食不安全和肝脏相关死亡率 (LRM) 之间的关系.
主要方法:
- 利用来自联合国的国家级粮食安全数据和来自2021年全球疾病负担研究的MASLD数据.
- 采用混合效应线性回归模型来分析关联,按社会人口指数 (SDI) 分层.
主要成果:
- 根据地区,MASLD的患病率差异很大,北非和中东地区的患病率最高.
- 在高SDI国家,增加的粮食不安全与更高的MASLD患病率相关;在低SDI国家观察到相反的情况.
- MASLD的患病率与肥胖,2型糖尿病和体力活动不足有关,而LRM与老年和代谢风险有关.
结论:
- MASLD的患病率和死亡率显示出严重的地理差异,受粮食不安全和临床人口统计因素的影响.
- 有针对性的,特定于区域的公共卫生战略对于减轻MASLD的全球负担至关重要.
- 解决食品质量,不健康的消费和获得医疗保健的问题,以及促进身体活动,对于MASLD管理至关重要.
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