小小的药丸,大大的影响:对儿科药物的内分泌干扰效应进行系统审查
L Tourvieilhe1, F Salvo2, V Bréant3
1Clinical Investigation Centre, CIC 1407, Hospices Civils de Lyon-INSERM, Bron, France.
Environmental toxicology and pharmacology
|August 29, 2024
概括
这次审查发现有限的证据表明,药物和精油可能在儿童中充当内分泌干扰化学物质 (EDC),影响生长和发育. 需要更强大的研究来确认这些潜在的风险.
科学领域:
- 环境健康 环境健康
- 儿科内分泌学 儿科内分泌学
- 毒理学 毒理学 毒理学
背景情况:
- 内分泌干扰化学物质 (EDC) 对儿童健康构成潜在风险.
- 药品和精油被确定为儿童群体EDC暴露的可能来源.
- 现有研究强调,需要调查儿童接触的物质的内分泌干扰潜力.
研究的目的:
- 系统地审查和评估儿科药物和精油中的物质作为内分泌干扰化学物质 (EDC) 对儿童的潜在影响.
- 确定与儿童内分泌功能障碍相关的特定药品和精油.
- 评估连接儿科药物暴露与内分泌干扰的证据质量.
主要方法:
- 使用PECOT (人口,暴露,比较,结果,时间) 方法对包括Medline在内的五个数据库进行系统审查.
- 纳入标准侧重于对暴露于药物 (活性成分或辅助成分) 的儿童进行的研究,这些儿童出现了内分泌功能障碍的临床症状.
- 分析了946项确定的研究,28项最终被纳入了审查中.
主要成果:
- 帕拉本,衣草精油和抗药物是与内分泌干扰相关的最常见的药物.
- 报告的健康结果包括对青春期的影响,甲状腺疾病,肥胖和生长.
- 大多数包含的研究都是案例报告,表明有限的有力的证据.
结论:
- 虽然存在潜在风险,但与儿科药物暴露与内分泌干扰化学物质 (EDCs) 相关的现有数据的整体质量有限.
- 目前的证据基础主要依赖于案例报告,突出显示了强有力的科学发现存在重大差距.
- 需要进一步进行高质量的研究,以建立明确的联系,并解决该领域潜在的利益冲突.
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