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孕产妇免疫细胞基因表达与孕产妇肠道微生物组,牛奶成分和婴儿肠道微生物组有关

Manoj Gurung¹, Bharath Kumar Mulakala², Brent Thomas Schlegel³

¹Microbiome and Metabolism Research Unit (MMRU), Southeast Area, USDA-ARS, Arkansas Children's Nutrition Center, Little Rock, AR, USA.

Clinical nutrition ESPEN

|August 29, 2024

概括

怀孕前超重会改变母亲免疫细胞的基因表达,尤其是在怀孕早期. 这些变化与母亲的饮食,肠道微生物和婴儿的结果有关,为与肥胖有关的健康策略提供了见解.

科学领域:

生殖免疫学生殖免疫学
代谢健康代谢健康
微生物组研究微生物组研究

背景情况:

孕产妇超重和肥胖对母亲和孩子都有很大的风险.
虽然肥胖对外围血液单核细胞 (PBMC) 基因表达的影响已知,但怀孕期间怀孕前超重的影响仍未得到充分研究.
了解这些影响对于母亲和婴儿健康结果至关重要.

研究的目的:

为了研究妊娠前超重对整个怀孕期间母亲免疫细胞基因表达的影响.
探索基因表达,母亲的饮食,肠道微生物群,牛奶成分和婴儿肠道微生物群之间的关联.
确定减轻肥胖引起的健康影响的潜在策略.

主要方法:

采集了正常体重 (NW) 和超重 (OW) 孕妇在怀孕12周,24周和36周的血液样本.
在分离的PBMC上进行mRNA测序,并对母婴肠道微生物群进行16SrRNA基因测序.
利用整合性多组学分析将基因表达与各种健康和微生物因素相关联.

主要成果:

与NW女性相比,OW女性的基因表达显著差异,特别是在怀孕12周时,炎症通路的丰富.
在36周,母亲的饮食和肠道微生物群与特定的基因表达有联系.
母亲的抗炎基因与婴儿肠道细菌 (Akkermansia) 有正相关,与牛奶寡糖类有负相关.

结论:

怀孕前超重显著影响母亲免疫细胞基因表达,特别是在怀孕早期.
孕产妇PBMC基因表达,孕产妇/婴儿肠道微生物群和牛奶成分之间的相互作用是复杂的.
这些发现可以为策略提供信息,以解决怀孕期间与肥胖相关的健康问题.

关键词:

免疫反应的免疫反应.炎症炎症是一种炎症.微生物群中的微生物群过重的过重的过重.这就是PBMCs.

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