美国成年人暴露于制阻燃剂和牙周炎之间的关联
Jia-Jie Lv1, Shu-Yue Li2, Xiang-Meng Kong3
1Department of Vascular Surgery, Shanghai Putuo People's Hospital, School of Medicine, Tongji University, No.1291 Jiangning Road, Huangpu District, Shanghai, 200060, China; Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, No.639 Zhizaoju Road, Huangpu District, Shanghai, 200011, China.
Chemosphere
|August 29, 2024
概括
接触制阻燃剂 (BFRs) 与牙周炎的风险更高有关. 较高的特定BFR血清水平,如PBDE-183和PBDE-99,显示出剂量反应关系与牙周炎风险增加.
科学领域:
- 环境健康 环境健康
- 牙周病学 牙周病学
- 毒理学 毒理学 毒理学
背景情况:
- 在牙周炎的发展中,越来越多地认识到环境因素.
- 制阻燃剂 (BFR) 是广泛存在的环境污染物.
- BFR暴露与牙周炎风险之间的联系尚未得到充分证实.
研究的目的:
- 在美国成年人群中调查血清BFR水平与牙周炎之间的关联.
- 确定导致牙周炎风险的特定BFR.
- 检查BFR和牙周炎之间的剂量反应关系.
主要方法:
- 利用了3322名NHANES参与者的数据 (2009-2016).
- 测量了10个BFR (PBDE和 PBB) 的血清水平.
- 使用后勤回归,WQS回归和BKMR来分析关联和混合物.
主要成果:
- 在几个BFR (例如,PBDE-28,PBDE-47,PBDE-183) 和牙周炎风险之间发现了显著的积极关联.
- 在许多BFR中观察到剂量反应关系.
- 确定了PBDE-183,PBDE-153,PBDE-209和PBDE-99为混合物效应的主要贡献者.
结论:
- 这项研究提供了证据,表明BFR暴露与美国成年人牙周炎风险增加有关.
- 特定BFR的血清水平升高与牙周炎有积极的关联.
- 这些发现突显了BFRs在牙周炎病原体中的潜在作用.
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