维生素D缺乏对慢性酒精性肝损伤的影响
Huihui Wang1, Weiyi Gong2, Jingxin Gao2
1Department of Nutrition and Hygiene, School of Public Health, Anhui Medical University, Hefei, 230032, China; Women's Group Insurance Department, Lianyungang Maternal and Child Health Hospital, Lianyungang, 222000, China.
Free radical biology & medicine
|August 29, 2024
概括
维生素D缺乏 (VDD) 通过破坏肠道健康和激活炎症途径,使酒精性肝损伤恶化. 补充维生素D可以预防酒精性脂肪性肝病 (AFLD).
科学领域:
- 肝病学 肝病学是一种肝病学.
- 营养科学 营养科学
- 免疫学 免疫学 免疫学
背景情况:
- 酒精性肝病 (ALD) 是一个严重的健康问题.
- 维生素D缺乏 (VDD) 在酒者中很普遍,但其在ALD中的作用尚不清楚.
- 了解VDD对酒精性脂肪性肝病 (AFLD) 的影响至关重要.
研究的目的:
- 为了研究AFLD患者的维生素D水平.
- 为了确定VDD对老鼠慢性酒精性肝损伤的影响.
- 阐明VDD对ALD的影响背后的分子机制.
主要方法:
- 在AFLD患者中测量了25-氧维生素D [25(OH) D].
- 使用了酒精性肝损伤的小鼠模型.
- 评估了肠道微生物群的组成,肠道紧结蛋白 (Occludin,E-cadherin),炎症细胞因子和NF-κB信号通路的激活.
主要成果:
- AFLD患者表现出较低的25(OH) D度,表明VDD.
- 25(OH) D被确定为AFLD的保护因素.
- 在小鼠中,VDD改变了肠道微生物群,降低了肠道屏障完整性,增加了肝脏和结肠炎症,并激活了NF-κB通路.
结论:
- 维生素D缺乏会加剧慢性酒精性肝损伤.
- VDD通过破坏肠道屏障功能并通过NF-κB激活促进炎症,从而导致ALD.
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