肠道超声波的可靠性,以评估克罗恩氏病的活动,使用点的护理和中央阅读
Thomas M Goodsall1, Yoon-Kyo An2, Jane M Andrews3
1IBD Service, Department of Gastroenterology, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia; Faculty of Health Sciences, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
概括
肠道超声波 (IUS) 显示了评估克罗恩氏病 (CD) 活动的中等可靠性. 集中读数和特定参数,如肠壁厚度,提高了临床试验的准确性.
科学领域:
- 胃肠病学 胃肠病学
- 医疗成像医学成像
- 临床试验 临床试验
背景情况:
- 肠道超声波 (IUS) 越来越多地用于克罗恩氏病 (CD) 活动评估.
- 临床试验IUS的应用受到不一致的评分和可靠性问题所阻碍.
研究的目的:
- 为了评估CD评估的本地和中央读取IUS参数的inter-和intra-rater可靠性.
- 在工作坊环境中前性分析特定IUS测量的可靠性.
主要方法:
- 24名CD患者和6名胃肠科医生参加了为期2天的研讨会.
- 通过本地和中央阅读器评估了8个IUS参数和整体超声波活动.
- 使用类内相关系数 (ICC) 量化可靠性.
主要成果:
- 五个IUS参数 (BWT,CDS,i-fat,粘膜下突出,受影响的细分长度) 显示了中等的inter-和intra-rater可靠性.
- 集中阅读通常比本地阅读更高可靠性.
- 对BWS和i-fat进行二元结果评估,并专注于受影响最严重的细分市场,提高了可靠性.
结论:
- 对于几个CD活动参数,本地和中央IUS读数显示中等可靠性.
- 这些发现支持完善IUS活动指数,并将中央IUS读数纳入临床试验.
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