预测慢性乙型肝炎病毒感染的功能治愈的预测因素:长期随访研究
Jia-Feng Wu1, Chi-San Tai2, Kai-Chi Chang2
1Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan; Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan.
概括
实现慢性乙型肝炎病毒 (HBV) 感染的功能治疗是可能的. 早期的B型肝炎抗原 (HBeAg) 血清转化,特定的抗病毒疗法和低水平的HBsAg预测了成功的结果.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 功能性治愈是治疗慢性乙型肝炎病毒 (HBV) 感染的关键目标.
- 在B型肝炎e抗原 (HBeAg) 血清转化后评估功能治愈的预测因素至关重要.
研究的目的:
- 评估HBeAg血清转换后慢性HBV患者的功能治愈的累积概率.
- 确定与实现功能治愈相关的重要预测因素.
主要方法:
- 对413名HBeAg阳性慢性HBV患者的回顾性分析,长期随访 (平均26.36年).
- 功能治愈的定义:在没有治疗的情况下持续失去HBsAg和HBVDNA超过24周.
- 多变量考克斯比例危险分析,以确定功能治愈的预测因素.
主要成果:
- 在10,888人年内,累计功能治愈概率为14.53%.
- 功能性治愈的预测因素包括在18岁之前的HBeAg血清转化,高遗传障碍核和t) 胺类比疗法,以及血清转化后18个月的HBsAg标位<1000 IU/mL.
- 在HBeAg血清转化后,每年的功能治愈率显著增加.
结论:
- 儿童HBeAg血清转化,特定抗病毒疗法和早期低HBsAg标位是慢性HBV中功能治愈的重要预测因素.
- 这些发现可以为治疗策略提供信息,旨在在HBV患者中实现功能治愈.
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