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视野在开始眼内压力降低后会改善吗?在英国玻璃眼治疗研究中?
Peter F Reddingius1, Stephen R Kelly1, Giovanni Ometto1
1From the Department of Optometry and Visual Sciences (P.F.R., S.R.K., G.O., D.P.C.), School of Health and Psychological Sciences, City, University of London, London, United Kingdom.
American journal of ophthalmology
|August 29, 2024
概括
新诊断的玻璃眼患者的早期视野状态没有通过降低眼内压力的治疗得到改善. 这项研究发现,治疗组和安慰剂组之间的视野变化没有显著差异.
科学领域:
- 眼科医生 眼科 眼科
- 玻璃眼研究研究 玻璃眼研究
- 视觉场分析 视觉场分析
背景情况:
- 降低眼内压力 (IOP) 是青光眼的主要治疗方法.
- 在开始IOP降压疗法后,支持视野 (VF) 改善的证据得到了讨论.
- 英国眼治疗研究 (UKGTS) 提供了数据来调查这一假设.
研究的目的:
- 为了确定视野状态是否在开始IOP降压治疗后改善新诊断的玻璃眼患者.
- 为了比较接受药物治疗的患者和接受安慰剂的患者之间的短期VF变化.
主要方法:
- 在UKGTS中利用了202名 (治疗) 和205名 (安慰剂) 新诊断的开角玻璃眼患者的资格和基线数据.
- 在治疗分配之前和之后比较了两个可靠的汉弗雷24-2 SITA标准VF和IOP测量.
- 在治疗和安慰剂组中分析了VF平均偏差 (MD) 的平均变化和MD改善的眼睛比例.
主要成果:
- 平均IOP降低为4.8mmHg (接受治疗) 与1.0mmHg (安慰剂) 在12周内.
- 在MD的平均变化是相似的: -0.03dB (治疗) 与+0.08dB (安慰剂) (P = .47).
- 患有≥1dBMD改善的参与者的比例在两组之间是可比的 (P = .25);没有发现与IOP降低大小的关联.
结论:
- 在UKGTS的治疗和安慰剂组中,最初的短期视野变化是相同的.
- 没有证据支持这样的假设,即在新诊断的非晚期玻璃眼中,初始内视压降低后通过医疗治疗改善视野状态.
- 可能需要进一步的研究来了解长期影响和最佳的治疗策略.
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