益生菌疗法调节大脑-肠-肝脏微生物群轴在创伤性脑损伤的小鼠模型中
Wellington Z Amaral1, Natalie Kokroko2, Todd J Treangen2
1Departments of Neurosurgery and Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.
Biochimica et biophysica acta. Molecular basis of disease
|August 29, 2024
概括
益生菌治疗通过调节肠道微生物群和肝脂来改善创伤性脑损伤 (TBI) 后的记忆力和神经可塑性. 这表明益生菌可能为TBI认知缺陷提供一种新的治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
背景情况:
- 肠道微生物群在宿主健康中起着至关重要的作用,影响大脑功能.
- 创伤性脑损伤 (TBI) 可以破坏肠道微生物群,影响恢复.
- 了解肠-大脑轴是开发TBI疗法的关键.
研究的目的:
- 调查益生菌治疗对TBI后肝脂质样本的影响.
- 评估益生菌对TBI后神经可塑性,记忆和炎症标志物的影响.
- 探索肠道微生物群组成和TBI中的肝脂质变化之间的关系.
主要方法:
- 在TBI小鼠中使用益生菌 (Lactobacillus helveticus和Bifidobacterium longum).
- 使用生物信息学工具分析了肠道微生物群的组成.
- 测量的肝脂类,葡萄糖代谢和炎症标志物.
- 通过行为测试和海马基因表达 (CaMKII,CREB,BDNF) 来评估认知功能.
主要成果:
- 益生菌治疗增加了TBI小鼠中的Firmicutes/Bacteroidetes比率.
- 创伤破坏了肠道细菌与肝脂相关性,并通过益生菌部分恢复.
- 益生菌改善了记忆力,逆转了CaMKII和CREB表达中的TBI诱导的缺陷,并影响了葡萄糖代谢.
- 益生菌没有显著改变促炎性标志物 (TNF-α,IL1-β) 或BDNF水平.
结论:
- 创伤诱导肠道失调并改变肝脏脂质概况,影响认知功能.
- 益生菌 (Lactobacillus helveticus和Bifidobacterium longum) 的使用可以减轻TBI相关的神经可塑性缺陷和记忆障碍.
- 益生菌通过调节肠道微生物群和肝脏脂质组学,显示出作为TBI治疗策略的潜力.
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