我如何在艾滋病毒感染者中管理传播的Mycobacterium avium复杂性疾病?
Tommaso Matucci1, Giacomo Pozza2, Angelo Roberto Raccagni3
1Department of Clinical and Experimental Medicine, Infectious Diseases Unit, Azienda Ospedaliero Universitaria Pisana, University of Pisa, Pisa, Italy; StopTB Italia ODV, Milan, Italy.
在晚期艾滋病毒疾病 (AHD) 患者中诊断和治疗传播的Mycobacterium avium复合体 (MAC) 疾病仍然具有挑战性. 需要指导,因为尽管有效的抗逆转录病毒治疗,死亡率很高.
科学领域:
- 传染性疾病 传染性疾病
- 艾滋病毒 医学 艾滋病毒 医学
- 临床微生物学 临床微生物学
背景情况:
- 晚期艾滋病毒疾病 (AHD) 正在增加,欧洲的晚期诊断很常见.
- 晚期呈现艾滋病毒 (PWH) 患者的高死亡率仍然存在,通常是由于机会性感染,如Mycobacterium avium复合体 (MAC).
- 传播性MAC疾病 (dMACd) 存在重大诊断和治疗障碍,影响患者的治疗结果.
研究的目的:
- 提供关于在艾滋病毒感染者 (PWH) 中诊断和治疗传播性MAC疾病 (dMACd) 的指导.
- 解决与AHD和dMACd的PWH管理中的挑战.
- 审查目前的流行病学,临床表现,诊断,预防,治疗和dMACd的未来前景.
主要方法:
- 使用PubMed进行了一项文献审查.
- 获取和分析了原始文章,元分析和系统评论.
- 对患有AHD和dMACd的PWH的关键管理步骤进行了审查和讨论.
主要成果:
- 传播性MAC疾病 (dMACd) 仍然是患有AHD的PWH患者疾病和死亡的重要原因,即使有有效的抗逆转录病毒疗法.
- 实现最终诊断的困难和延迟是持续的挑战.
- 利法素在dMACd治疗中的作用是一个正在进行的讨论领域.
结论:
- 有效的抗逆转录病毒治疗并没有消除与dMACd相关的死亡率在PWH与AHD.
- 诊断延迟和挑战仍然是管理dMACd的关键问题.
- 关于dMACd治疗中利法素的最佳使用,需要进一步的研究和共识.
更多相关视频
07:21Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment
Published on: June 23, 2019
09:57Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens
Published on: February 14, 2011
相关概念视频
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
Immunodeficiency Diseases
There are three main causes of immunodeficiency...
Retrovirus Life Cycles
Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
