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血清白蛋白与老年营养风险指数和中国老年男性骨质疏松症之间的关联:一项嵌套病例对照研究
Ting Li1, Jing Zeng1, Xinyu Miao1
1Department of Endocrinology, the Second Medical Centre & National Clinical Research Centre for Geriatric Disease, Chinese PLA General Hospital, Beijing, China.
Asia Pacific journal of clinical nutrition
|August 29, 2024
概括
较低的血清白蛋白和老年营养风险指数得分与中国老年男性患骨质疏松症的风险较高有关. 这些营养标记可以帮助预测这一群体的骨健康状况.
科学领域:
- 老年医学 老年医学
- 营养科学 营养科学
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 营养不良是骨质疏松症的一个已知的危险因素.
- 评估营养状况对于管理老年人骨健康至关重要.
研究的目的:
- 调查血清白蛋白 (ALB) 和老年营养风险指数 (GNRI) 与中国老年男性骨质疏松风险之间的关联.
- 评估ALB和GNRI对骨质疏松症发展的预测价值.
主要方法:
- 一项嵌套病例对照研究涉及1109名个人,对其进行了7年的跟踪.
- 使用ALB和GNRI评估的营养状况.
- 使用多变量考克斯回归,ROC曲线分析 (AUC) 和卡普兰-梅尔曲线.
主要成果:
- 更高的ALB水平 (HR:0.821) 和GNRI得分 (HR:0.889) 与骨质疏松症的风险降低有关.
- 在ROC分析中,ALB (AUC:0.729) 和GNRI (AUC:0.731) 的预测值显著.
- 卡普兰-梅尔曲线显示了各子组ALB和GNRI的显著差异 (p<0.001).
结论:
- 较低的血清白蛋白和GNRI得分与中国老年男性骨质疏松症的更高患病率显著相关.
- 在这个人口群体中,ALB和GNRI是预测骨质疏松症风险的有价值指标.
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