健康的中国5岁以下儿童的网细胞血红蛋白等效的参考值及其与各种血液参数的关联
Keith Tsz Suen Tung1, Chen Chen1, Yung Tuen Chiu2
1Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, People's Republic of China.
BMJ paediatrics open
|August 29, 2024
概括
对于香港五岁以下的儿童,建立了回细胞血红蛋白等效 (RET-He) 参考范围. 婴儿的较低RET-He水平表明,针对年龄的铁缺乏症查至关重要.
科学领域:
- 血液学 血液学 血液学
- 儿科医学 儿科医学
- 临床化学 临床化学
背景情况:
- 网细胞血红蛋白等效 (RET-He) 是最近铁利用的关键指标,独立于炎症.
- 确定儿童RET-He的特定年龄参考范围对于准确的评估至关重要.
研究的目的:
- 为了确定健康的香港5岁以下儿童的RET-He的参考范围.
- 在这个人群中调查RET-He和其他血液学参数之间的相关性.
主要方法:
- 一项涉及946名年龄在2至48个月的儿童的横截面研究.
- 使用自动分析仪和免疫测试,测量了血液学参数,包括RET-He和费里丁.
- 统计分析包括回归和ROC曲线分析,以确定正常范围和确定缺铁值.
主要成果:
- RET-He水平显示了近似的正常分布,年龄特定的下限从25.81 pg到27.15 pg不等.
- 在2-12个月的婴儿中观察到较低的平均RET-He水平.
- RET-He受年龄,红细胞参数和网红细胞计数 (p<0.05) 的显著影响.
- 为了检测缺铁,确定了≤27.8 pg的RET-He截止值.
结论:
- 儿童的RET-He水平随年龄而异,婴儿的RET-He水平较低.
- 特定于年龄的RET-He的下限是儿童群体初步缺铁查的宝贵工具.
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