肠道微生物群特征和循环代谢物与儿童系统性炎症的关联
Bruno Bohn1,2, Curtis Tilves1,2, Yingan Chen1,2
1Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
BMJ open gastroenterology
|August 29, 2024
概括
肠道微生物及其代谢物,特别是酸-氨酸-氨酸路径中的代谢物,与儿童的炎症有关. 微生物依赖的代谢物与非微生物依赖的代谢物相比,与炎症标志物的关联性更强.
科学领域:
- 微生物组研究的研究.
- 代谢学 代谢学 代谢学
- 儿科免疫学 儿科免疫学
背景情况:
- 肠道微生物群及其代谢物影响全身炎症.
- 在儿童中,微生物群-代谢物-炎症轴内的特定相互作用尚不清楚.
研究的目的:
- 调查肠道微生物组成,循环代谢物和儿童炎症标志物之间的关联.
- 区分微生物依赖与非微生物依赖代谢物在儿科炎症中的作用.
主要方法:
- 在儿科队列 (n=321) 中分析了血代谢组,肠道微生物群 (16S rRNA测序) 和炎症标志物 (PAI-1,MCP-1,TNF-α).
- 检查微生物种群,微生物依赖和非微生物依赖代谢物与炎症标志物和整体炎症评分之间的关联.
- 为混因素进行调整,为多重比较进行校正.
主要成果:
- 335种微生物种类中的149种和1037种代谢物中的87种与炎症标志物有关.
- 微生物依赖的代谢物比非微生物依赖的代谢物更频繁地与炎症标志物 (PAI-1,InfSc) 相关联.
- 具体的代谢物,如金氨酸和血清胺,显示出积极的关联,而托显示出与炎症的反向关联.
结论:
- 一个独特的肠道微生物和微生物依赖代谢物的群体,特别是在托 - - 氨酸 - - 氨酸通路内,都与儿童炎症有关.
- 这些发现凸显了肠道微生物群-代谢物轴在儿科炎症过程中的潜在作用.
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