直接刺激前面的胰岛和中腹前额叶皮层会破坏经济选择
Romane Cecchi1,2,3, Antoine Collomb-Clerc4,5, Inès Rachidi4,6
1Univ. Grenoble Alpes, Inserm, U1216, CHU Grenoble Alpes, Grenoble Institut Neurosciences, 38000, Grenoble, France. romane.cecchi@gmail.com.
Nature communications
|August 29, 2024
概括
风中前额叶皮层 (vmPFC) 和前端岛叶 (aIns) 的电刺激揭示了与经济选择的因果关系. 特定的子区域影响风险承担和信心,表明决策的不同神经回路.
科学领域:
- 神经科学是一个神经科学.
- 决策科学 决策科学 决策科学
- 计算精神病学是一种计算精神病学.
背景情况:
- 腹中介前额叶皮层 (vmPFC) 和前端岛 (aIns) 中的神经活动与经济选择和信心相关.
- 这些大脑区域在决策中的因果作用在很大程度上仍未得到研究.
研究的目的:
- 调查vmPFC与aIns活动与经济决策之间的因果关系,包括风险承担和信心.
- 在选择任务中探索这些大脑区域内的功能解离.
主要方法:
- 在执行经济选择任务的患者中使用内电刺激 (iES).
- 分析了aIns和vmPFC内的不同背腹部部位刺激对冒险和信心的影响.
主要成果:
- 腹部aIns的刺激通过增加损失敏感性来降低风险承担;背部aIns和腹部vmPFC的刺激通过降低损失敏感性来增加风险承担.
- 前部胰岛刺激始终降低了信心,无论刺激地点如何.
- 在aIns和vmPFC中展示了功能上不同的子区域.
结论:
- 在vmPFC和aIns中的神经子区域因果关系地参与经济选择,在风险评估中发挥着不同的作用.
- 这些发现突出了在决策中接受或避免挑战的基础上的功能分离电路.
- iES提供了一个强大的工具,用于阐明复杂行为中的因果神经机制.
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