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Updated: Jun 14, 2025

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二维机械敏感的OSCA/TMEM63通道的激活机制

Yuanyue Shan1,2, Mengmeng Zhang1, Meiyu Chen1

  • 1Laboratory of Cell Fate Control, School of Life Sciences, Westlake University, Hangzhou, 310000, China.

Nature communications
|August 29, 2024
PubMed
概括

机械敏感的OSCA/TMEM63通道,对于感知机械力至关重要,通过独特的孔隙扩张机制激活. 酸胆 (Lyso-PC) 结合进一步调节这种激活,揭示了对传送器类通道功能的洞察力.

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