超同胞蛋白血症及其对衰老和语言功能的影响 - - HEAL研究
G Sandhya1, S Monisha1, Sadhana Singh1
1Centre for Brain Research, Indian Institute of Science, Bengaluru, India.
Scientific reports
|August 29, 2024
概括
在45岁以上的成年人中,高水平的homocysteine与较差的词汇技能和减少的大脑白质量量有关. 这表明同类氨酸对大脑的功能和结构都有影响.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 生物化学 生物化学
背景情况:
- 过高homocysteinemia,血中的同类氨酸 (Hcy) 水平升高 (>15μmol/L),与影响大脑健康和认知的血管和神经退行性途径有关.
- 了解高Hcy对老年人群认知功能和大脑结构的具体影响,对于开发有针对性的干预措施至关重要.
研究的目的:
- 研究中年和老年人中高水平homocysteine与认知表现之间的关联.
- 为了检查同一个队列中高水平的同型半氨酸与大脑体积变化,特别是大脑白质量体积之间的关系.
主要方法:
- 从塔塔长度老化研究 (TLSA) 招募了1296名年龄≥45岁的参与者.
- 使用ACE-III和COGNITO神经心理电池进行了全面的认知评估.
- 利用3T磁共振成像进行大脑体积分析,并根据中位数 (16.89μmol/L) 将参与者分为低Hcy和高Hcy组.
主要成果:
- 经过调整后的分析显示,高Hcy与在词汇任务上的表现较差之间存在显著的关联 (p=0.041).
- 高水平的Hcy与大脑白质体积的减少显著相关 (p=0.043).
结论:
- 成年人高水平的homocysteine与认知功能受损有关,特别是在语言领域.
- 高水平的homocysteine与大脑结构的变化有关,特别是白质体积的减少,这表明对大脑完整性的有害影响.
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