亚洲人中与肥胖和2型糖尿病相关的单核酸多态 (SNP):系统性审查和元分析
Kevina Yanasegaran1, Jeremy Yung Ern Ng1, Eng Wee Chua1
1Centre for Drug and Herbal Development, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, 50300, Kuala Lumpur, Malaysia.
Scientific reports
|August 29, 2024
概括
特定的单核酸多态 (SNP) 与亚洲人群中肥胖和2型糖尿病 (T2DM) 的风险增加有关. 这一元分析确定了潜在的基因查小组的关键SNP,以评估疾病易感性.
科学领域:
- 遗传学和基因组学 遗传学和基因组学
- 代谢疾病 代谢疾病
- 人口健康 人口健康
背景情况:
- 单核酸多态 (SNP) 与肥胖和2型糖尿病 (T2DM) 易感性有关.
- 肥胖和T2DM具有共同的病理生理联系,这表明它们具有共同的遗传媒介.
- 与西方群体相比,亚洲人群中SNP关联的研究有限.
研究的目的:
- 在亚洲人群中系统地审查和元分析与肥胖和2型糖尿病 (T2DM) 相关的单核酸多态 (SNP).
- 确定特定的SNP,使这些代谢条件的风险增加.
主要方法:
- 在六个数据库中进行了全面的文献搜索.
- 用Review Manager (RevMan) 进行了元分析.
- 聚合几率比率 (ORs) 和95%置信区间 (CI) 使用随机效应模型进行计算.
主要成果:
- 三个SNP (FTO中的rs9939609,MC4R中的rs17782313和rs571312) 显示与肥胖有显著的关联 (ORs1.37,1.36,1.29).
- 五个SNP (rs7903146,rs12255372在TCF7L2;rs13266634,rs11558471在SLC30A8;rs2283228在KCNQ1) 与T2DM有很强的关联 (ORs 1.64, 1.61, 1.22, 1.29, 1.60). 这两种SNP都与T2DM有很强的关联.
结论:
- 已识别的SNP为亚洲人的肥胖和T2DM风险提供了有价值的遗传标记.
- 这些数据支持开发基因查小组,以评估对肥胖和T2DM的易感性.
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