基于CT的放射学用于预测乳腺癌放射治疗副作用
Óscar Llorián-Salvador1,2,3, Nora Windeler4, Nicole Martin5
1Department of Radiation Oncology, Klinikum Rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675, Munich, Germany. oscar.llorian-salvador@tum.de.
来自CT扫描的放射性特征可以预测乳房放射治疗后的皮肤炎症,类似于使用乳房总体积. 乳腺组织的放射学比腺组织更好地预测这些副作用.
科学领域:
- 在瘤学瘤学.
- 医疗成像医学成像
- 辐射疗法 辐射疗法
背景情况:
- 乳腺放射疗法 (RT) 通常会引起急性皮肤副作用,如炎症,湿性上皮质溶解和.
- 预测这些副作用对于改善患者护理和治疗计划至关重要.
研究的目的:
- 为了比较来自组织的放射学特征的预测值与乳房总体积 (TBV) 以预测潮湿上皮质解和水.
- 评估机器学习模型的性能,使用放射学和临床特征来预测RT诱导的皮肤毒性.
主要方法:
- 从252名乳腺癌患者的计算机断层扫描 (CT) 中提取了放射性特征.
- 从感兴趣的乳房总体积 (TBV) 和腺组织 (GT) 区域分析了特征.
- 包括LASSO在内的机器学习分类器经过训练和评估,以预测皮肤副作用.
主要成果:
- 使用TBV特征的最佳放射学模型实现了AUROC0.74的预测潮湿上皮质溶解,与单独使用TBV (AUROC0.75) 相比.
- 乳腺组织放射学显示出比腺组织更高的预测价值.
- 除了与体积相关的特征,预测性能略有下降 (AUROC 0.71).
结论:
- 基于CT的放射学模型显示了预测乳腺放射治疗引起的皮肤副作用的潜力.
- 来自乳腺组织的放射性特征比腺组织的放射性特征更具预测性.
- 放射学特征的预测性能受其与乳腺总体积的相关性影响.
更多相关视频
10:17Guidelines and Experience Using Imaging Biomarker Explorer IBEX for Radiomics
Published on: January 8, 2018
04:09Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma
Published on: October 10, 2018
相关概念视频
Computed Tomography
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
Positron Emission Tomography
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
Radiological Investigation I: X-ray and CT
Radiological Investigation III: Pulmonary Angiogram and PET Scan
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Imaging Studies II: Positron Emission Tomography and Scintigraphy
Fundamental Principles of PET
Imaging Studies III: Computed Tomography
