在接受心脏收缩性调制的患者中期临床结果和心脏功能
Andrew Deak1, Syed M Zaidi1, Chethan Gangireddy1
1Department of Medicine, Section of Cardiology, Parkinson Pavilion, 9th Floor, 3401 North Broad Street, Philadelphia, PA, 19140, USA.
概括
心脏收缩性调制 (CCM) 疗法改善了心力衰竭症状,减少了住院治疗,并在中期城市患者队列中增强了缩和腹缩功能. 患者在CCM治疗后也经历了显著的体重减轻.
科学领域:
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
- 医疗器械 医疗器械
背景情况:
- 心脏收缩性调制 (CCM) 是一种新兴的治疗系统性心力衰竭的疗法 (NYHA III类,EF 25-45%).
- CCM对扩张功能障碍和体重变化的影响仍然在很大程度上未被探索.
- 了解CCM的广泛临床影响对于优化心力衰竭管理至关重要.
研究的目的:
- 在城市心力衰竭患者群体中评估CCM治疗的中期临床和功能结果.
- 评估CCM对纽约心脏协会 (NYHA) 课程,住院,喷射分数 (EF) 和透气功能 (DD) 的影响.
- 为了研究CCM对患者体重的影响.
主要方法:
- 连续31名接受CCM植入物的患者的回顾性审查.
- 对NYHA类,住院,EF,DD和体重的CCM前后植入物数据进行比较.
- 统计分析以确定观察到的变化的重要性.
主要成果:
- 在NYHA类 (0.97类,p<0.001) 和68%的患者显著改善.
- 减少了平均每年住院住院次数 (0.8比0.4/年,p=0.048) 和住院日数 (p<0.001在异常值排除后).
- 平均EF增加了8% (p=0.002),DD改善了0.8级 (p<0.001),患者平均减轻了4%的体重 (p=0.002).
结论:
- 在城市心力衰竭队列中,CCM治疗显示出显著的中期益处.
- 在多个临床参数中观察到改善,包括功能类,心脏功能和体重.
- 这些发现支持CCM作为选择心力衰竭患者的有价值的治疗选择.
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