年龄是否影响移植患者免疫抑制药物药理动力学?
Amelia R Cossart1, Nicole M Isbel2, Scott B Campbell2
1School of Pharmacy, University of Queensland, 20 Cornwall Street, Woolloongabba, Brisbane, QLD, 4102, Australia. amelia.cossart@uqconnect.edu.au.
European journal of drug metabolism and pharmacokinetics
|August 29, 2024
概括
随着年龄的增长,mycophenolic acid (MPA) 的药理动力学显著受到影响,从而增加了老年人的暴露. 塔克罗利马斯和普雷迪尼索隆没有显示出与年龄相关的显著药理动力学差异.
科学领域:
- 药理学 药理学是指药理学的学科.
- 老年医学 老年医学
- 移植医学 移植医学
背景情况:
- 免疫抑制药物的药理动力学可以随着年龄的增长而改变,这可能会影响移植结果.
- 了解与年龄相关的药物动力学变化对于优化老年人群中药物治疗至关重要.
研究的目的:
- 调查年龄对塔克罗利斯,酸和普雷迪尼索隆的药理动力学和暴露参数的影响.
- 为了比较年长和年轻的成年移植接受者之间的这些参数.
主要方法:
- 在老年和年轻的成年人中,对塔克罗利斯,基酸 (MPA),基酸葡萄化物 (MPAG) 和普雷迪尼索隆的药理动力学概况.
- 在剂后多个时间点进行血液和血样本分析.
- 年龄组之间的非分区分析和统计比较 (曼-惠特尼测试).
主要成果:
- 年长的成年人表现出明显更高的MPA和MPAG的最小和最大度,低度和半衰期.
- 在老年人中,自由MPA暴露量是老年人的两倍 (经剂量调整的中位数AUC0-12:1284比684μg h/L,p < 0.0001).
- 年龄与自由MPA和MPAG暴露有显著的关联;自由MPA也与血有关.
结论:
- 随着年龄的增长,药物动力学发生了变化,并增加了对酸 (MPA) 和其代谢物MPAG的暴露.
- 这些与年龄相关的MPA差异可能归因于功能,血红素,血蛋白结合或药物吸收的变化.
- 需要进一步的研究来阐明对这些观察到的药理动力学变异的特定共变量贡献.
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