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针对性RT研究:针对性治疗和放射治疗的早期毒性结果

Dinah Konnerth¹, Aurelie Gaasch², C Benedikt Westphalen^3,4,5

¹Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany. dinah.konnerth@med.uni-muenchen.de.

Radiation oncology (London, England)

|August 29, 2024

概括

在癌症患者中,将放射治疗 (RT) 与向治疗 (TT) 结合起来被发现是可行的,并且耐受良好. 这项研究发现,当与RT同时使用向治疗时,毒性没有显著增加.

科学领域:

在瘤学瘤学.
辐射疗法辐射疗法
药理学药理学是指药理学的学科.

背景情况:

关于将向治疗 (TT) 与放射治疗 (RT) 结合在一起的前性数据有限.
评估并发TT和RT的可行性和毒性对于癌症治疗至关重要.
需要加强对TT和放射治疗同时使用的证据基础.

研究的目的:

为了前性地评估结合RT与癌症患者的同时TT的耐受性和可行性.
评估与放射治疗一起使用的各种向治疗的毒性概况.
扩大有关并发TT和RT安全性的现有证据.

主要方法:

在单一机构进行的前性研究 (2020年3月至2021年12月).
包括经组织学确认的癌症患者,接受外部光束放射治疗,同时接受TT.
使用国家癌症研究所常用术语标准对不良事件v5.0进行毒性评估;以DRKS00026193.0注册.

主要成果:

334名患者接受了683个RT系列与51种不同的并发TT物质.
整体来说,RT和TT的组合耐受性很好,没有观察到严重的急性毒性.
疲劳 (轻度至中度) 是最常见的毒性;由于轻度副作用,只有4.7%的患者停止了TT.

结论:

将放射治疗与并发向治疗相结合并没有显著增加毒性.
需要进一步的研究,以探索与RT使用的各种TT剂的特定毒性概况.
该研究支持在癌症患者具有可控毒性的同时TT和RT的可行性.

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