体质指数和阿尔茨海默氏症标志物之间的不同关联取决于代谢健康状况
Eun Hye Lee1, Heejin Yoo1,2, Young Ju Kim1,2
1Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.
Alzheimer's research & therapy
|August 29, 2024
概括
代谢健康显著影响身体质量指数 (BMI) 与阿尔茨海默病 (AD) 标志物之间的关系. 在代谢上保持健康可以减轻与肥胖和阿尔茨海默病相关的风险,并有可能改善认知结果.
科学领域:
- 神经科学是一个神经科学.
- 代谢健康 代谢健康
- 衰老研究研究 衰老研究
背景情况:
- 越来越多的证据将身体质量指数 (BMI) 与阿尔茨海默病 (AD) 和血管标志物联系起来.
- 代谢不健康的条件越来越多地被认为对这些标记物的影响.
- 这项研究调查了BMI和代谢健康状况如何与AD和血管标志物相互作用.
研究的目的:
- 检查身体质量指数 (BMI) 对阿尔茨海默病 (AD) 和血管标记物的影响.
- 评估代谢健康状况在BMI和这些标志物之间的关系中所起的改变作用.
- 探索对认知功能和大脑结构的影响.
主要方法:
- 招募了1,736名非痴呆症的亚洲人,根据BMI (体重不足,正常,肥胖) 和代谢健康 (代谢健康[MH]与代谢不健康[MU]) 分类他们.
- 评估结果包括粉样β (Aβ) 阳性和严重的白质超强度 (WMH).
- 使用后勤回归,调解分析 (海马体积[HV],迷你精神状态检查[MMSE]) 和线性混合模型用于纵向MMSE变化.
主要成果:
- 体重不足增加了Aβ阳性风险;肥胖降低了它,特别是在代谢健康 (MH) 组.
- 肥胖与严重白质超强度 (WMH) 的风险增加有关.
- 降低的Aβ阳性度调解了MH组中肥胖和更高的HV/MMSE得分之间的关联,肥胖显示MMSE下降速度较慢.
结论:
- 代谢健康状况显著调节肥胖和阿尔茨海默病 (AD) 生物标志物之间的关系.
- 这些发现表明,保持代谢健康可以改变肥胖对AD标志物的影响,从而可能导致更好的临床结果.
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