结合PCT和CRP比在重症监护室的细菌性病患者的单独测试更好:一项回顾性研究
Guo-Ming Zhang1,2, Xu-Xiao Guo3
1Department of Laboratory Medicine, Shuyang Hospital, The Affiliated Shuyang Hospital of Xuzhou Medical University, Shuyang, 223600, Jiangsu, People's Republic of China. gm@xzhmu.edu.cn.
European journal of medical research
|August 29, 2024
概括
组合C-反应蛋白 (CRP) 和前素 (PCT) 测试有助于诊断成年ICU患者的细菌性尿症. 这些标记物显示出更高的敏感性和Candida感染的负预测值.
科学领域:
- 密集护理医学 密集护理医学
- 临床化学 临床化学
- 传染性疾病 传染性疾病
背景情况:
- 尿路感染 (UTI) 研究往往不包括成年人.
- 这项研究侧重于成人ICU患者的细菌性尿.
研究的目的:
- 评估中性粒细胞与淋巴细胞比率 (NLR),C反应蛋白 (CRP) 和前素 (PCT) 对成人ICU患者细菌病的预测值.
主要方法:
- 一项病例控制研究,涉及85名细菌尿患者和136名ICU中的对照患者.
- 通过医院信息系统收集的数据.
- 用于评估NLR,CRP和PCT预测性能的接收器操作特征 (ROC) 曲线.
主要成果:
- 甲素 (PCT) 显示了最高的曲线下面面积 (AUC) 值为0.884,其次是C反应蛋白 (CRP) 值为0.855,中性粒细胞与淋巴细胞的比率 (NLR) 为0.711.
- 确定了NLR (8.02),CRP (18.52 mg/L) 和PCT (0.215 ng/mL) 的最佳值.
- CRP显示了比PCT更高的负预测值 (NPV). 无论是CRP还是PCT都表现出与Candida相关的细菌性尿症的增强敏感性和NPV.
结论:
- 结合CRP和PCT测试可以改善成年ICU患者的细菌尿诊断.
- CRP和PCT特别有效,具有更高的灵敏度和NPV,用于诊断由Candida感染引起的细菌尿.
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