[肠道微生物群的相对丰富性和特拉精子症之间的因果关系:双样本孟德尔随机化分析]
Xiao-Hui Hao1, Rui-Min Ma1, Si-Cheng Ma1
1Henan University of Chinese Medicine, Zhengzhou, Henan 450046, China.
Zhonghua nan ke xue = National journal of andrology
|August 29, 2024
概括
一些肠道细菌,包括Erysipelotrichia和Streptococcaceae,可能会增加类精子症的风险. 相反,Porphyromonadaceae似乎具有保护性,可能改善精子形态并降低风险.
科学领域:
- 微生物组研究的研究.
- 生殖健康 生殖健康
- 遗传学 遗传学 是一个
背景情况:
- 具有异常精子形态的特征,是男性不孕症的一个重要因素.
- 肠道微生物群在包括生殖功能在内的全身健康中的作用是一个新兴的研究领域.
研究的目的:
- 调查特定的肠道微生物种群与类精子症的风险之间的潜在因果关系.
- 为了利用大规模的遗传数据进行强有力的因果推断.
主要方法:
- 使用两个样本的门德尔随机化 (MR) 分析.
- 使用的全基因组协会研究 (GWAS) 关于肠道微生物群 (MiBioGen,18,340名参与者) 和三种子 (85,716名个人,915例) 的数据.
- 应用了反变量加权 (IVW),MR-Egger和加权中位数估计器 (WME) 方法.
主要成果:
- 几种肠道微生物种群,包括Erysipelotrichia类,Erysipelotrichaceae家族,Streptococcaceae家族,Coprococcus属,Ruminococcaceae属UCG009,Streptococcus属,Clostridiales序列和Erysipelotrichales序列,都与生精子症的风险增加有关.
- 葡萄家族 Porphyromonadaceae 显示与降低类精子症的风险有显著的关联.
结论:
- 特定的肠道细菌,如Erysipelotrichia和Streptococcaceae,被认为是类精子发育的潜在因果因素.
- 肠道微生物家族Porphyromonadaceae可能会对精子形态产生保护作用,降低类精子的风险.
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