在中国人口中,血压变化对心血管疾病的风险分析
1School of Public Health, Inner Mongolia Medical University, Hohhot, China.
Journal of clinical hypertension (Greenwich, Conn.)
|August 30, 2024
概括
血压的变化显著影响中国成年人的心血管事件风险. 持续高血压会增加风险,而恢复正常水平可能会降低风险.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 心血管疾病 (CVD) 仍然是全球主要的死亡原因.
- 了解血压 (BP) 波动对心血管疾病风险的影响对于预防策略至关重要.
- 2017年ACC/AHA高血压指南为定义BP状态提供了一个框架.
研究的目的:
- 评估血压状况变化与心血管事件发生率之间的关联.
- 评估与不同基线血压水平和随时间变化的血压相关的心血管疾病风险,在中国人口中.
- 调查持续高血压和血压正常化对心血管疾病风险的影响.
主要方法:
- 一项包括33179名中国参与者 (≥35岁,57.1%的女性) 没有基线心血管疾病的队列研究.
- 血压状况根据2017年ACC/AHA高血压指南进行分类.
- 对血压变化的分析:稳定<130/80 mmHg,<130/80 至 ≥130/80 mmHg,≥130/80 至 <130/80 mmHg,持续≥130/80 mmHg.
- 考克斯比例危险和细灰模型用于估计发生心血管疾病的危险比率 (HR) 在3.17年的中位随访期间.
主要成果:
- 基线血压水平为120-129/<80 mmHg (HR=1.66),130-139/80-89 mmHg (HR=1.35) 和≥140/90 mmHg (HR=2.46) 与<120/80 mmHg相比,与心血管疾病风险增加有关.
- 与稳定的血压<130/80 mmHg相比,持久的血压≥130/80 mmHg显示心血管疾病风险明显更高 (HR=1.88).
- 从较高类别的血压下降到<130/80 mmHg,与心血管疾病风险降低有关 (HR=1.40).
结论:
- 血压升高的类别,包括120-129/<80 mmHg,与中国人口心血管事件的风险更高有关.
- 持续高血压 (≥130/80 mmHg) 随着时间的推移显著提高心血管疾病风险.
- 从高血压状态达到正常血压水平 (<130/80 mmHg) 可以减轻心血管风险.
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