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Updated: Jun 14, 2025

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
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抑制了电压关闭的质子通道HCNL1

Makoto F Kuwabara1, Joschua Klemptner1, Julia Muth1

  • 1Department of Neurophysiology, Institute of Physiology and Pathophysiology, Philipps University Marburg, Marburg, Germany.

Biophysical journal
|August 30, 2024
PubMed
概括

离子 (Zn2+) 通过高极化激活的HCNL1通道抑制质子电流. 这种抑制通过多种机制发生,根据Zn2+是否在细胞外或细胞内被应用而产生不同的效果,突出其在HCNL1功能中的作用.

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