在肺高血压患者中补充氧气的流行病学
Rodrigo Torres-Castro1,2,3, Williams Hinojosa4, Amaya Martínez-Meñaca5,6,7
1Department of Pulmonary Medicine, Hospital Clínic, University of Barcelona, Barcelona, Spain.
Respirology (Carlton, Vic.)
|August 30, 2024
概括
在肺动脉高血压 (PAH) 和慢性血栓栓塞性肺高血压 (CTEPH) 患者中,长期氧气治疗 (LTOT) 的患病率约为20%. 功能类,6分钟的步行距离和血液动力学测量预测了LTOT的处方.
科学领域:
- 肺部医学 肺部医学
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 肺高血压 (PH) 可能导致低氧化,需要长期氧气治疗 (LTOT).
- 对于PH患者的LTOT处方存在有限的流行病学数据.
- 本研究涉及西班牙PAH和CTEPH患者中LTOT的流行,发病率和预测因素.
研究的目的:
- 分析PAH和CTEPH的西班牙患者中LTOT处方的流行率和发病率.
- 在这些患者群体中确定LTOT启动的预测因子.
主要方法:
- 西班牙肺动脉高血压登记处 (REHAP) 的回顾性分析.
- 包括人口统计,功能类别,血液气体,肺功能,血液动力学和6分钟步行距离 (6MWD) 的数据.
- 根据PH组和亚型评估LTOT的流行和发病率,并对LTOT启动进行预测分析.
主要成果:
- 分析了4533名患者 (69.9%的PAH,30.1%的CTEPH),平均年龄为53.0岁,64.5%是女性.
- LTOT的流行率为19.3%;发病率从5.6%降至1.6% (2010-2019).
- LTOT的预测因素包括功能类,6MWD,平均肺动脉压 (mPAP),心脏指数 (CI),肺血管阻力 (PVR) 和一氧化碳 (DLCO) 扩散能力.
结论:
- 大约20%的PAH和CTEPH患者接受LTOT.
- 功能类,6MWD,mPAP,CI,PVR和DLCO是这些患者LTOT处方的重要预测因素.
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