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与卵子捐赠者相比,青少年的卵子微环境发生了变化
Dilan Gokyer1, Sophia Akinboro1,2, Luhan T Zhou1
1Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Human reproduction open
|August 30, 2024
概括
在接受生育保护的青少年中,卵子周围的分子环境与卵子捐赠者的不同,这影响了生殖潜力咨询. 这项研究分析了累积细胞和卵泡液的分子特征.
科学领域:
- 生殖生物学和内分泌学.
- 分子和细胞生物学分子和细胞生物学
- 基因组学和转录基因组学
背景情况:
- 青少年可能经历经月经后的子育能力,可能是由于生殖性青春期卵子细胞积率增加和卵子细胞质量低于最佳.
- 了解卵细胞微环境对于评估雌性体质量至关重要,特别是在接受生育保护的青少年中.
研究的目的:
- 为了调查积细胞 (CCs) 和卵泡液 (FF) 的分子特征是否在接受生育保护的青少年和成年卵细胞捐赠者之间有所不同.
- 为了了解青少年卵细胞微环境的变化,以改善生育保护咨询.
主要方法:
- 前性队列研究比较青少年 (10-19岁) 和卵细胞捐赠者 (22-30岁).
- 大量RNA测序分析了成熟卵细胞中CCs的转录组.
- 细胞因子阵列分析了两组的FF.
主要成果:
- 观察到CC基因表达的显著差异,细胞循环/分裂途径下调的基因和青少年细胞/囊泡组织上调的基因.
- 与捐赠者相比,青少年的FF显著增加了9种细胞因子,其中许多具有促炎作用.
- 在患有或没有癌症的青少年之间,没有发现CC转录组或FF细胞因子配置的差异.
结论:
- 在接受生育保护的青少年中,直接的卵细胞微环境,包括CC和FF,发生了变化.
- 这些发现对辅导青少年生殖潜力和优化生育保护策略有影响.
- 需要对卵细胞进行进一步的直接研究,尽管具有挑战性,以更准确地评估生殖潜力.
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