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Updated: Jun 14, 2025

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies
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基于三素的MS可切割的交叉链接质谱仪用于剖析蜂网络的多重体相互作用

Clinton Yu, Eric Novitsky, Xiaorong Wang

    bioRxiv : the preprint server for biology
    |August 30, 2024
    PubMed
    概括

    一种新的交叉连接试剂,TSTO,通过识别三元连接,可以准确地绘制蛋白质与蛋白质相互作用 (PPI) 的地图. 这推动了结构系统生物学,揭示了活细胞中复杂的结构细节.

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    相关概念视频

    Mass Spectrometry: Complex Analysis01:21

    Mass Spectrometry: Complex Analysis

    Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
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