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Updated: Jun 14, 2025

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM
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Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM

Published on: May 8, 2020

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主导性恶性克隆 杆血统 限制表观基因组程序来驱动膜瘤的发展

Alisha Kardian, Hua Sun, Siri Ippagunta

    bioRxiv : the preprint server for biology
    |August 30, 2024
    PubMed
    概括

    儿科内膜瘤 (EPN) 转变是由ZFTA-RELA融合蛋白驱动的,其向特定的发育性脑细胞程序. 这些瘤蛋白在发育过程中劫持可访问的染色质,启动瘤生长并建立细胞层次结构.

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    Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice

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    Abnormal Proliferation

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    Induced Pluripotent Stem Cells

    Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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