维护味觉受体细胞的前突触部位需要味觉神经纤维
bioRxiv : the preprint server for biology
|August 30, 2024
概括
神经纤维连接对于味蕾突触形成至关重要. 来自味觉神经的营养因子促使味觉细胞构建突触前机器,指导神经元重新连接并维持味觉功能.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
- 感官生物学 感官生物学
背景情况:
- 外围味觉突触的循环是味觉信息中继的重要组成部分.
- 味觉突触组合和特异性的机制在很大程度上仍然未知.
研究的目的:
- 研究神经纤维连接在味觉突触组合中的作用.
- 为了确定神经内置是否会在味觉受体细胞中启动前突触机器的招募.
主要方法:
- 检查了味觉细胞中CALHM1和Bassoon前突触蛋白的表达.
- 在味觉神经切割和再生后,分析了前突触部位密度和mRNA转录水平的变化.
主要成果:
- 预突触部位 (Bassoon,CALHM1) 在脱皮后显著减少,表明神经依赖.
- 贝索恩和卡尔姆1的mRNA表达在失去神经后下降.
- 在再生过程中,前突触部位补充了,但与对照组相比,神经连接性较低 (~50%).
结论:
- 味觉神经内化对于味觉突触的维护和组装至关重要.
- 神经元的接近,可能由营养因子介导,驱动突触前蛋白质的表达和聚合.
- 这一过程可能引导成熟的突触形成,并有助于味蕾的突触可塑性.
相关概念视频
The Physiology of Taste
3.8K
The perception of a salty flavor is facilitated by sodium ions within the oral salivary fluid. Upon consumption of a salty substance, salt crystals disassemble, leading to the liberation of its constituents—Na+ and Cl- ions. These ions subsequently dissolve into the salivary fluid present in the oral cavity. The external environment of the gustatory cells experiences an elevation in Na+ concentration, thereby establishing a potent concentration gradient. This gradient propels the...
3.8K
Gustation
47.7K
Gustation is a chemical sense that, along with olfaction (smell), contributes to our perception of taste. It starts with the activation of receptors by chemical compounds (tastants) dissolved in the saliva. The saliva and filiform papillae on the tongue distribute the tastants and increase their exposure to the taste receptors.
47.7K
Taste Buds and Receptors
1.9K
Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...
1.9K
G-Protein Gated Ion Channels
4.5K
GPCRs are primarily responsible for our sense of smell, taste, and vision. The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...
Sensory...
4.5K
Olfactory Receptors: Location and Structure
9.1K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.1K
Physiology of Smell and Olfactory Pathway
8.2K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...
8.2K


