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Updated: May 10, 2026

CRISPR-Cas9-based Genome Engineering to Generate Jurkat Reporter Models for HIV-1 Infection with Selected Proviral Integration Sites
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CRISPR-Cas9-based Genome Engineering to Generate Jurkat Reporter Models for HIV-1 Infection with Selected Proviral Integration Sites

Published on: November 14, 2018

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一个有针对性的CRISPR屏幕将ETS1识别为HIV潜伏时间的调节者

Manickam Ashokkumar, Terry L Hafer, Abby Felton

    bioRxiv : the preprint server for biology
    |August 30, 2024
    PubMed
    概括

    转录因子ETS1对于通过调节病毒表达和宿主细胞通路来维持人类免疫缺陷病毒 (HIV) 延迟至关重要. 它的耗尽会影响治疗个体的艾滋病毒储备.

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    相关概念视频

    CRISPR/Cas9 Genome Editing01:28

    CRISPR/Cas9 Genome Editing

    The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...